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Clobenpropit dihydrobromide
CAS No. 145231-35-2
Clobenpropit dihydrobromide ( —— )
Catalog No. M21942 CAS No. 145231-35-2
Clobenpropit dihydrobromide is a potent ?antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)Clobenpropit inhibited cell migration and increased apoptosis of pancreatic cancer cells in combination with gemcitabine.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 312 | In Stock |
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| 50MG | 528 | In Stock |
|
| 100MG | 755 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameClobenpropit dihydrobromide
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NoteResearch use only, not for human use.
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Brief DescriptionClobenpropit dihydrobromide is a potent ?antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)Clobenpropit inhibited cell migration and increased apoptosis of pancreatic cancer cells in combination with gemcitabine.?
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DescriptionClobenpropit dihydrobromide is a potent ?antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)Clobenpropit inhibited cell migration and increased apoptosis of pancreatic cancer cells in combination with gemcitabine.?Clobenpropit up-regulated E-cadherin, but down-regulated vimentin and matrix metalloproteinase 9 in real-time polymerase chain reaction.?Clobenpropit inhibited tumor growth (gemcitabine 294 46 mg vs combination 154 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorH3 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number145231-35-2
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Formula Weight470.7
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Molecular FormulaC14H19Br2ClN4S
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Purity>98% (HPLC)
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Solubility——
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SMILESBr.Br.Clc1ccc(CNC(=N)SCCCc2cnc[nH]2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mena-Avila E, et al. Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes. Pharmacol Rep. 2018 Feb;70(1):146-155.
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